Vaccination with Live or Heat-Killed Aspergillus fumigatus ΔsglA Conidia Fully Protects Immunocompromised Mice from Invasive Aspergillosis

ABSTRACT Aspergillus fumigatus causes invasive aspergillosis (IA) in immunocompromised patients, resulting in high mortality rates. Currently, no vaccine formulations to promote immune protection in at-risk individuals have been developed. In this work, we deleted the sterylglucosidase-encoding gene...

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Detalhes bibliográficos

Principais autores:	Caroline Mota Fernandes, Tyler G. Normile, Joao Henrique Tadini Marilhano Fabri, Veronica Soares Brauer, Glauber R. de S. Araújo, Susana Frases, Leonardo Nimrichter, Iran Malavazi, Maurizio Del Poeta
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2022-10-01
coleção:	mBio
Assuntos:	fungal infection Aspergillus invasive aspergillosis vaccine sterylglucosides immunocompromised host
Acesso em linha:	https://journals.asm.org/doi/10.1128/mbio.02328-22
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