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Mincle receptor agonist UM-1098 and TLR4 agonist INI-2002 combination adjuvant enhances Th1 responses and provides protection against Mycobacterium tuberculosis challenge in mice

Adjuvants targeting pattern recognition receptors (PRRs) can selectively skew the immune responses towards a Th1, Th2 or Th17 phenotype following vaccination. However, for diseases such as tuberculosis (TB), mixed Th cell responses, especially Th1/Th17 are considered important for protection. Hence,...

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Principais autores: Viktoria Rungelrath, Grace Jones, Mushtaq Ahmed, Vibha Taneja, Alexander Riffey, Walid M. Abdelwahab, Shibali Das, Shabaana A. Khader, Jay T. Evans
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-10-01
Serier:Vaccine: X
Fag:
Tuberculosis
Mincle
TLR4
Th1/Th17
Adjuvant
M72
Online adgang:http://www.sciencedirect.com/science/article/pii/S2590136225000932
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