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Mincle-dependent Th17 adjuvanticity requires TNFR1 signaling in myeloid cells

Successful induction of protective T cells by recombinant protein vaccines requires adjuvants. The liposomal adjuvant system CAF01 induces robust Th17 responses in mice. CAF01 contains the synthetic glycolipid trehalose-6,6-dibehenate (TDB), whose recognition by the C-type lectin receptor Mincle is...

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Principais autores: Robert Blamberg, Carl Haberkamp, Gabriel Kristian Pedersen, Ida Rosenkrands, Ulrike Schleicher, Barbara U. Schraml, Sho Yamasaki, Roland Lang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-02-01
Serier:Frontiers in Immunology
Fag:
CAF01
Mincle
TDB
TDM
Th17
TNF
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1746618/full
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