Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

<p>Abstract</p> <p>Background</p> <p>Glutathione (GSH) plays an important role in neuronal oxidant defence. Depletion of cellular GSH is observed in neurodegenerative diseases and thereby contributes to the associated oxidative stress and Ca²⁺dysregulation. Whether depletion of cellular...

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Autores principales:	Belrose Jillian C, Xie Yu-Feng, Gierszewski Lynn J, MacDonald John F, Jackson Michael F
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2012-04-01
Colección:	Molecular Brain
Materias:	TRPM2 Aging Glutathione Oxidative stress Pyramidal neuron Primary hippocampal culture
Acceso en línea:	http://www.molecularbrain.com/content/5/1/11
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