Evaluation of a reference antibody panel for prediction of cytokine release in humanised mouse models in vivo

IntroductionA diverse range of innovative biological therapies is being developed to treat various human diseases. The safety assessment of these biologics is a critical factor determining clinical success. Enhanced humanised mouse models have the potential to revolutionise immunotoxicological profi...

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Bibliografiske detaljer

Principais autores:	Deepa Rajagopal, Ka Seng Ieong, Ryan Mate, Sandrine Vessillier
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2026-03-01
Serier:	Frontiers in Immunology
Fag:	cytokine release hazard identification human peripheral blood mononuclear cells (PBMC) humanised mouse models NOD-scid-gamma (NSG) mice preclinical safety assessment
Online adgang:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1736130/full
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