Evaluation of a reference antibody panel for prediction of cytokine release in humanised mouse models in vivo

IntroductionA diverse range of innovative biological therapies is being developed to treat various human diseases. The safety assessment of these biologics is a critical factor determining clinical success. Enhanced humanised mouse models have the potential to revolutionise immunotoxicological profi...

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Autors principals:	Deepa Rajagopal, Ka Seng Ieong, Ryan Mate, Sandrine Vessillier
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-03-01
Col·lecció:	Frontiers in Immunology
Matèries:	cytokine release hazard identification human peripheral blood mononuclear cells (PBMC) humanised mouse models NOD-scid-gamma (NSG) mice preclinical safety assessment
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1736130/full
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