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Smad7 and protein phosphatase 1α are critical determinants in the duration of TGF-β/ALK1 signaling in endothelial cells

<p>Abstract</p> <p>Background</p> <p>In endothelial cells (EC), transforming growth factor-β (TGF-β) can bind to and transduce signals through ALK1 and ALK5. The TGF-β/ALK5 and TGF-β/ALK1 pathways have opposite effects on EC behaviour. Besides differential receptor binding, the duration of TGF-β sig...

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Váldodahkkit: Heldin Carl-Henrik, Itoh Susumu, Itoh Fumiko, Goumans Marie-José, Valdimarsdottir Gudrun, Dijke Peter
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2006-03-01
Ráidu:BMC Cell Biology
Liŋkkat:http://www.biomedcentral.com/1471-2121/7/16
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