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Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness

ABSTRACT Despite our extensive knowledge of the genetic regulation of heat shock proteins (HSPs), the evolutionary routes that allow bacteria to adaptively tune their HSP levels and corresponding proteostatic robustness have been explored less. In this report, directed evolution experiments using th...

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Principais autores: Julien Mortier, Elisa Gayán, Ronald Van Eyken, Oscar Enrique Torres Montaguth, Ladan Khodaparast, Laleh Khodaparast, Bert Houben, Sebastien Carpentier, Frederic Rousseau, Joost Schymkowitz, Abram Aertsen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021-08-01
coleção:mBio
Assuntos:
evolution
genetics
heat resistance
protein aggregates
Acesso em linha:https://journals.asm.org/doi/10.1128/mBio.01129-21
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