A bactericidal tuberculosis drug regimen driven by inhibition of the terminal oxidases by pretomanid

Abstract Pretomanid is a unique anti-tuberculosis agent that inhibits both cell-wall synthesis and bioenergetics in Mycobacterium tuberculosis. While targeting the cell wall triggers a rapid bactericidal effect on replicating mycobacteria, the release of nitric oxide is linked to bactericidal potenc...

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Auteurs principaux:	Nurlilah Ab Rahman, Samsher Singh, Thomas Wiggins, May Delos Santos, Garrett C Moraski, Marvin J Miller, Michael Berney, Kevin Pethe
Format:	Artigo
Langue:	Inglês
Publié:	Springer Nature 2026-02-01
Collection:	EMBO Molecular Medicine
Sujets:	Telacebec Oxidative Phosphorylation Drug Combination Antimicrobial Resistance Terminal Oxidase
Accès en ligne:	https://doi.org/10.1038/s44321-026-00378-9
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