Syntheses and Structure–Activity Relationships of <i>N</i>-Phenethyl-Quinazolin-4-yl-Amines as Potent Inhibitors of Cytochrome <i>bd</i> Oxidase in <i>Mycobacterium tuberculosis</i>

The development of cytochrome <i>bd</i> oxidase (cyt-<i>bd</i>) inhibitors are needed for comprehensive termination of energy production in <i>Mycobacterium tuberculosis</i> (Mtb) to treat tuberculosis infections. Herein, we report on the structure-activity-relationships (SAR) of 22 new <i>N</i>-phe...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Sarah M. Hopfner, Bei Shi Lee, Nitin P. Kalia, Marvin J. Miller, Kevin Pethe, Garrett C. Moraski
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2021-09-01
Edice:	Applied Sciences
Témata:	tuberculosis drug development structure–activity relationships quinazoline energy metabolism cytochrome <i>bd</i> oxidase
On-line přístup:	https://www.mdpi.com/2076-3417/11/19/9092
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!