Targeting Myeloid-Derived Suppressor Cells to Enhance the Antitumor Efficacy of Immune Checkpoint Blockade Therapy

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that are activated under pathological conditions, such as cancer, or mature myeloid cells that are converted immune-suppressive cells via tumor-derived exosomes, and potently support the tumor processes...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Xueyan Li, Jiahui Zhong, Xue Deng, Xuan Guo, Yantong Lu, Juze Lin, Xuhui Huang, Changjun Wang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2021-12-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	myeloid-derived suppressor cells (MDSCs) immune checkpoint blockade (ICB) therapy immunosuppression programmed cell death protein 1 (PD-1) the tumor microenvironment (TME)
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.754196/full
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