Myeloid-derived suppressor cells in colorectal cancer: mechanisms of immunosuppression, therapy resistance and therapeutic targeting

The overall response of colorectal cancer (CRC) to immune checkpoint blockade remains limited, particularly in patients with microsatellite-stable disease. One important underlying mechanism is the involvement of myeloid-derived suppressor cells (MDSCs) in shaping an immunosuppressive TME. Under the...

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Principais autores:	Haoyi Zhang, Wenyue Liu, Yutong Zhang, Shuchen Chen, Gongping Sun
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-06-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	colorectal cancer immune checkpoint blockade immunotherapy resistance myeloid-derived suppressor cells tumor microenvironment
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1840613/full
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