3,3′-Diindolylmethane improves antitumor immune responses of PD-1 blockade via inhibiting myeloid-derived suppressor cells

Abstract Background Immune checkpoint inhibitors that target programmed cell death protein 1 (PD-1) have obtained encouraging results, but a fraction of tumor patients failed to respond to anti-PD-1 treatment due to the existence of multiple immune suppressive elements such as myeloid-derived suppre...

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Autori principali:	Qi Sun, Lin Xiao, Zhiying Cui, Yaping Yang, Junting Ma, Zhen Huang, Junfeng Zhang, Jiangning Chen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2022-06-01
Serie:	Chinese Medicine
Soggetti:	3,3′-Diindolylmethane Cancer immunotherapy Adjunctive therapy PD-1 blockade Myeloid-derived suppressor cells
Accesso online:	https://doi.org/10.1186/s13020-022-00638-z
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