Decitabine assists umbilical cord-derived mesenchymal stem cells in improving glucose homeostasis by modulating macrophage polarization in type 2 diabetic mice

Abstract Background Mesenchymal stem cells (MSCs) have emerged as a promising therapy for type 2 diabetes (T2D). Mechanistic researches demonstrate that the anti-diabetic effect of MSCs is partially mediated by eliciting macrophages into an anti-inflammatory phenotype thus alleviating insulin resist...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Jieqing Gao, Yu Cheng, Haojie Hao, Yaqi Yin, Jing Xue, Qi Zhang, Lin Li, Jiejie Liu, Zongyan Xie, Songyan Yu, Bing Li, Weidong Han, Yiming Mu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2019-08-01
Schriftenreihe:	Stem Cell Research & Therapy
Schlagworte:	Mesenchymal stem cells Insulin resistance Decitabine Macrophage polarization Diabetes
Online-Zugang:	http://link.springer.com/article/10.1186/s13287-019-1338-2
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