Preclinical profiling of antibody drug conjugates targeting oncofetal chondroitin sulfate

Abstract Antibody-drug conjugates (ADC) offer a targeted cancer treatment approach by delivering cytotoxic payloads directly to tumor cells. However, resistance mechanisms, poor tumor penetration, and off-target toxicity often limit clinical efficacy. Vartumab targets oncofetal chondroitin sulfate (...

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Bibliografiske detaljer

Principais autores:	Ann Skafte, Elena Ethel Vidal-Calvo, Swati Choudhary, Joana Mujollari, Robert Dagil, Anne Martin-Salazar, Htoo Zarni Oo, Lara Duvnjak, Thor G. Theander, Mads Daugaard, Tobias Gustavsson, Ali Salanti
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2026-01-01
Serier:	Cell Death and Disease
Online adgang:	https://doi.org/10.1038/s41419-026-08420-x
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