Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages

Summary: Mendelian susceptibility to mycobacterial disease (MSMD) is caused by inborn errors of interferon gamma (IFNγ) immunity and is characterized by severe infections by weakly virulent mycobacteria. Although IFNγ is the macrophage-activating factor, macrophages from these patients have never be...

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Auteurs principaux:	Anna-Lena Neehus, Jenny Lam, Kathrin Haake, Sylvia Merkert, Nico Schmidt, Adele Mucci, Mania Ackermann, Madline Schubert, Christine Happle, Mark Philipp Kühnel, Patrick Blank, Friederike Philipp, Ralph Goethe, Danny Jonigk, Ulrich Martin, Ulrich Kalinke, Ulrich Baumann, Axel Schambach, Joachim Roesler, Nico Lachmann
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2018-01-01
Collection:	Stem Cell Reports
Sujets:	hematopoiesis iPSC macrophages MSMD IFNγR1 mycobacteria
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2213671117305180
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