Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages

Summary: Mendelian susceptibility to mycobacterial disease (MSMD) is caused by inborn errors of interferon gamma (IFNγ) immunity and is characterized by severe infections by weakly virulent mycobacteria. Although IFNγ is the macrophage-activating factor, macrophages from these patients have never be...

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Detalhes bibliográficos

Principais autores:	Anna-Lena Neehus, Jenny Lam, Kathrin Haake, Sylvia Merkert, Nico Schmidt, Adele Mucci, Mania Ackermann, Madline Schubert, Christine Happle, Mark Philipp Kühnel, Patrick Blank, Friederike Philipp, Ralph Goethe, Danny Jonigk, Ulrich Martin, Ulrich Kalinke, Ulrich Baumann, Axel Schambach, Joachim Roesler, Nico Lachmann
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2018-01-01
coleção:	Stem Cell Reports
Assuntos:	hematopoiesis iPSC macrophages MSMD IFNγR1 mycobacteria
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213671117305180
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