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Structural insight into TPX2-stimulated microtubule assembly

During mitosis and meiosis, microtubule (MT) assembly is locally upregulated by the chromatin-dependent Ran-GTP pathway. One of its key targets is the MT-associated spindle assembly factor TPX2. The molecular mechanism of how TPX2 stimulates MT assembly remains unknown because structural information...

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Principais autores: Rui Zhang, Johanna Roostalu, Thomas Surrey, Eva Nogales
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2017-11-01
Serier:eLife
Fag:
cryo-EM
microtubule
nucleation
cell division
dynamic instability
Ran-GTP
Online adgang:https://elifesciences.org/articles/30959
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