Structural insight into TPX2-stimulated microtubule assembly

During mitosis and meiosis, microtubule (MT) assembly is locally upregulated by the chromatin-dependent Ran-GTP pathway. One of its key targets is the MT-associated spindle assembly factor TPX2. The molecular mechanism of how TPX2 stimulates MT assembly remains unknown because structural information...

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Autors principals:	Rui Zhang, Johanna Roostalu, Thomas Surrey, Eva Nogales
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2017-11-01
Col·lecció:	eLife
Matèries:	cryo-EM microtubule nucleation cell division dynamic instability Ran-GTP
Accés en línia:	https://elifesciences.org/articles/30959
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