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Morphine Differentially Alters the Synaptic and Intrinsic Properties of D1R- and D2R-Expressing Medium Spiny Neurons in the Nucleus Accumbens

Exposure to opioids reshapes future reward and motivated behaviors partially by altering the functional output of medium spiny neurons (MSNs) in the nucleus accumbens shell. Here, we investigated how morphine, a highly addictive opioid, alters synaptic transmission and intrinsic excitability on dopa...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Dillon S. McDevitt, Benjamin Jonik, Nicholas M. Graziane
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019-12-01
Schriftenreihe:Frontiers in Synaptic Neuroscience
Schlagworte:
nucleus accumbens
morphine
opioid use disorder
intrinsic excitability
synaptic transmission
neuronal activity
Online-Zugang:https://www.frontiersin.org/article/10.3389/fnsyn.2019.00035/full
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