Morphine Differentially Alters the Synaptic and Intrinsic Properties of D1R- and D2R-Expressing Medium Spiny Neurons in the Nucleus Accumbens

Exposure to opioids reshapes future reward and motivated behaviors partially by altering the functional output of medium spiny neurons (MSNs) in the nucleus accumbens shell. Here, we investigated how morphine, a highly addictive opioid, alters synaptic transmission and intrinsic excitability on dopa...

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Detalles Bibliográficos

Principais autores:	Dillon S. McDevitt, Benjamin Jonik, Nicholas M. Graziane
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2019-12-01
Series:	Frontiers in Synaptic Neuroscience
Assuntos:	nucleus accumbens morphine opioid use disorder intrinsic excitability synaptic transmission neuronal activity
Acceso en liña:	https://www.frontiersin.org/article/10.3389/fnsyn.2019.00035/full
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