FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
Summary: Poly(ADP-ribose) polymerase inhibitors (PARPis) exhibit remarkable anticancer activity in tumors with homologous recombination (HR) gene mutations. However, the role of other DNA repair proteins in PARPi-induced lethality remains elusive. Here, we reveal that FANCM promotes PARPi resistance...
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| Principais autores: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2024-07-01
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| Serier: | Cell Reports |
| Fag: | |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S2211124724007939 |
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