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Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments

This study clarifies the long-standing misuse of emetine as a lagging strand synthesis-specific inhibitor. Emetine blocks the synthesis of both DNA strands by the inhibition of protein biosynthesis. DNA synthesis of the leading and lagging strands works independently and cells tolerate single-strand...

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Detaylı Bibliyografya
Asıl Yazarlar: David Lukac, Zuzana Machacova, Pavel Moudry
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Life Science Alliance LLC 2022-12-01
Seri Bilgileri:Life Science Alliance
Online Erişim:https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202201560
Etiketler: Etiketle
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