Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments
This study clarifies the long-standing misuse of emetine as a lagging strand synthesis-specific inhibitor. Emetine blocks the synthesis of both DNA strands by the inhibition of protein biosynthesis. DNA synthesis of the leading and lagging strands works independently and cells tolerate single-strand...
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| Principais autores: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Life Science Alliance LLC
2022-12-01
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| Serier: | Life Science Alliance |
| Online adgang: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202201560 |
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