FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition

Summary: Poly(ADP-ribose) polymerase inhibitors (PARPis) exhibit remarkable anticancer activity in tumors with homologous recombination (HR) gene mutations. However, the role of other DNA repair proteins in PARPi-induced lethality remains elusive. Here, we reveal that FANCM promotes PARPi resistance...

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Detalhes bibliográficos

Principais autores:	Zeyuan Liu, Huadong Jiang, Sze Yuen Lee, Nannan Kong, Ying Wai Chan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-07-01
coleção:	Cell Reports
Assuntos:	CP: Molecular biology
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124724007939
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