The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane
Summary: Tumor suppressor PTEN, the second most highly mutated protein in cancer, dephosphorylates signaling lipid PIP3 produced by PI3Ks. Excess PIP3 promotes cell proliferation. The mechanism at the membrane of this pivotal phosphatase is unknown hindering drug discovery. Exploiting explicit solve...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2021-05-01
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| Col·lecció: | iScience |
| Matèries: | |
| Accés en línia: | http://www.sciencedirect.com/science/article/pii/S2589004221004065 |
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