Non-redundant roles of the phosphoinositide phosphatases PTEN and PIPP in PI3K/AKT signaling in breast cancer

Abstract Phosphoinositide 3-kinase (PI3K) signaling is hyperactivated in ~70% of breast cancers via mutations in oncogenes including PIK3CA or inactivation/depletion of phosphoinositide (PI)-phosphatases. Generation of PI(3,4,5)P3 by PI3K activates many downstream effectors, including AKT, that indu...

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Үндсэн зохиолчид:	Lisa M. Ooms, Daniel T. Ferguson, Samuel J. Rodgers, Karmanpreet K. Sukhija, Emily I. Jones, Mariah P. Csolle, Hon Yan Kelvin Yip, Roger J. Daly, Tony Tiganis, Catriona A. McLean, Antonella Papa, Christina A. Mitchell
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2025-12-01
Цуврал:	Communications Biology
Онлайн хандалт:	https://doi.org/10.1038/s42003-025-09364-2
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!