ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2.

Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial and sporadic Parkinson's disease. The multidomain protein LRRK2 exhibits overall low GTPase and kinase activity in vitro.Here, we show that the rho guanine nucleotide exchange factor ARHGEF7 and the small G...

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Библиографические подробности

Главные авторы:	Karina Haebig, Christian Johannes Gloeckner, Marta Garcia Miralles, Frank Gillardon, Claudia Schulte, Olaf Riess, Marius Ueffing, Saskia Biskup, Michael Bonin
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2010-10-01
Серии:	PLoS ONE
Online-ссылка:	http://europepmc.org/articles/PMC2966438?pdf=render
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