Conformational diversity in purified prions produced in vitro.
Prion diseases are caused by misfolding of either wild-type or mutant forms of the prion protein (PrP) into self-propagating, pathogenic conformers, collectively termed PrPSc. Both wild-type and mutant PrPSc molecules exhibit conformational diversity in vivo, but purified prions generated by the ser...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2023-01-01
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| coleção: | PLoS Pathogens |
| Acesso em linha: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011083&type=printable |
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