Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage

Soluble HIV-1 envelope glycoprotein (Env) trimers are under active investigation as vaccine candidates in relevant pre-clinical models. Like SOSIPs, the cleavage-independent native flexibly linked (NFL) trimers are faithful mimics of the Env spike. Here, we analyzed multiple new designs to explore a...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Lifei Yang, Shailendra Kumar Sharma, Christopher Cottrell, Javier Guenaga, Karen Tran, Richard Wilson, Anna-Janina Behrens, Max Crispin, Natalia de Val, Richard T. Wyatt
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-07-01
coleção:	Frontiers in Immunology
Assuntos:	HIV-1 Env soluble trimer vaccines antigens stability antigenicity
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01631/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!