Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA

Self-amplifying mRNA (saRNA) represents a promising platform for nucleic acid delivery of vaccine immunogens. Unlike plasmid DNA, saRNA does not require entry into the nucleus of target cells for expression, having the capacity to drive higher protein expression compared to mRNA as it replicates wit...

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書目詳細資料

Principais autores:	Yoann Aldon, Paul F. McKay, Jorge Moreno Herrero, Annette B. Vogel, Réka Lévai, Pauline Maisonnasse, Nathalie Dereuddre-Bosquet, Heinrich Haas, Katalin Fábián, Roger Le Grand, Ugur Sahin, Robin J. Shattock
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2021-09-01
叢編:	Molecular Therapy: Nucleic Acids
主題:	saRNA HIV Env vaccine polyplexes PEI
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2162253121001499
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