Liraglutide, a glucagon-like peptide-1 receptor agonist, ameliorates inflammation and apoptosis via inhibition of receptor for advanced glycation end products signaling in AGEs induced chondrocytes

Abstract Background This study aimed to investigate functions of GLP-1R agonist by liraglutide (LIRA) and revealing the mechanism related to AGEs/RAGE in chondrocytes. Methods To illustrate potential effect of GLP-1R agonist on AGEs induced chondrocytes, chondrocytes were administrated by AGEs with...

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Detalhes bibliográficos

Principais autores:	Xianyu Zhang, Jian Jiang, Jiajia Xu, Jian Chen, Yuntao Gu, Guobao Wu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-07-01
Colecção:	BMC Musculoskeletal Disorders
Assuntos:	GLP-1R Liraglutide Osteoarthritis RAGE AGEs
Acesso em linha:	https://doi.org/10.1186/s12891-024-07640-6
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