Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial

Abstract Background The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce deaths from intracranial bleeding after traumatic brain injury (TBI). To explore the mechanism of action of TXA in TBI, we examined the timing of its effect on death. Methods The CRASH-3 trial...

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Principais autores:	Amy Brenner, Antonio Belli, Rizwana Chaudhri, Timothy Coats, Lauren Frimley, Sabariah Faizah Jamaluddin, Rashid Jooma, Raoul Mansukhani, Peter Sandercock, Haleema Shakur-Still, Temitayo Shokunbi, Ian Roberts, On behalf of the CRASH-3 trial collaborators
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-11-01
coleção:	Critical Care
Assuntos:	Traumatic brain injury Tranexamic acid CRASH-3 trial Randomised controlled trial Intracranial haemorrhage Epidemiology
Acesso em linha:	http://link.springer.com/article/10.1186/s13054-020-03243-4
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