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Tranexamic acid to reduce head injury death in people with traumatic brain injury: the CRASH-3 international RCT

Background: Tranexamic acid safely reduces mortality in traumatic extracranial bleeding. Intracranial bleeding is common after traumatic brain injury and can cause brain herniation and death. We assessed the effects of tranexamic acid in traumatic brain injury patients. Objective: To assess the effe...

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Principais autores: Ian Roberts, Haleema Shakur-Still, Amy Aeron-Thomas, Danielle Beaumont, Antonio Belli, Amy Brenner, Madeleine Cargill, Rizwana Chaudhri, Nicolas Douglas, Lauren Frimley, Catherine Gilliam, Amber Geer, Zahra Jamal, Rashid Jooma, Raoul Mansukhani, Alec Miners, Jason Pott, Danielle Prowse, Temitayo Shokunbi, Jack Williams
Formato: Artigo
Idioma:Inglês
Publicado em: NIHR Journals Library 2021-04-01
coleção:Health Technology Assessment
Assuntos:
tranexamic acid
cost–benefit analysis
time to treatment
quality-adjusted life-years
blood pressure
neurosurgery
global health
glasgow coma
intention-to-treat analysis
antifibrinolytic agents
intracranial hemorrhages
hemorrhage
craniocerebral trauma
brain injuries
traumatic
stroke
tomography
computed
intensive care units
Acesso em linha:https://doi.org/10.3310/hta25260
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