Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer

Abstract Background Immunostimulatory therapies targeting immune-suppressive pathways produce durable responses in advanced solid tumors. Indoleamine 2,3-dioxygenase (IDO) is the rate-limiting oxidoreductase that catalyzes the degradation of tryptophan to kynurenine. IDO induces immune tolerance by...

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Hlavní autoři:	Daniel E. Carvajal-Hausdorf, Nikita Mani, Vamsidhar Velcheti, Kurt A. Schalper, David L. Rimm
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMJ Publishing Group 2017-10-01
Edice:	Journal for ImmunoTherapy of Cancer
Témata:	IDO1 Hormone receptor-positive Survival Tumor-infiltrating lymphocytes Quantitative immunofluorescence
On-line přístup:	http://link.springer.com/article/10.1186/s40425-017-0285-7
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