Alveolar macrophage transcriptional signatures associated with resistance to TST/IGRA conversion following Mycobacterium tuberculosis exposure

Abstract Despite heavy exposure to Mycobacterium tuberculosis (Mtb), some individuals are resistant to TST and IGRA conversion (RSTRs). The functional and immunological mechanisms governing resistance are poorly understood. We hypothesized that RSTR and LTBI alveolar macrophages (AMs) respond differ...

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Главные авторы:	Austin M. Haynes, Cristian Ovadiuc, Glenna J. Peterson, William Worodria, Sophie Nalukwago, Timothy Muwanguzi, Mary Nsereko, Catherine M. Stein, Kimberly A. Dill-McFarland, Harriet Mayanja-Kizza, W. Henry Boom, R. Max Segnitz, Thomas R. Hawn
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2025-10-01
Серии:	BMC Genomics
Предметы:	Tuberculosis Alveolar macrophages Resisters Transcriptome
Online-ссылка:	https://doi.org/10.1186/s12864-025-12165-w
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