Alveolar macrophage transcriptional signatures associated with resistance to TST/IGRA conversion following Mycobacterium tuberculosis exposure

Abstract Despite heavy exposure to Mycobacterium tuberculosis (Mtb), some individuals are resistant to TST and IGRA conversion (RSTRs). The functional and immunological mechanisms governing resistance are poorly understood. We hypothesized that RSTR and LTBI alveolar macrophages (AMs) respond differ...

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Autori principali:	Austin M. Haynes, Cristian Ovadiuc, Glenna J. Peterson, William Worodria, Sophie Nalukwago, Timothy Muwanguzi, Mary Nsereko, Catherine M. Stein, Kimberly A. Dill-McFarland, Harriet Mayanja-Kizza, W. Henry Boom, R. Max Segnitz, Thomas R. Hawn
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-10-01
Serie:	BMC Genomics
Soggetti:	Tuberculosis Alveolar macrophages Resisters Transcriptome
Accesso online:	https://doi.org/10.1186/s12864-025-12165-w
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