Alveolar macrophage transcriptional signatures associated with resistance to TST/IGRA conversion following Mycobacterium tuberculosis exposure

Abstract Despite heavy exposure to Mycobacterium tuberculosis (Mtb), some individuals are resistant to TST and IGRA conversion (RSTRs). The functional and immunological mechanisms governing resistance are poorly understood. We hypothesized that RSTR and LTBI alveolar macrophages (AMs) respond differ...

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主要な著者:	Austin M. Haynes, Cristian Ovadiuc, Glenna J. Peterson, William Worodria, Sophie Nalukwago, Timothy Muwanguzi, Mary Nsereko, Catherine M. Stein, Kimberly A. Dill-McFarland, Harriet Mayanja-Kizza, W. Henry Boom, R. Max Segnitz, Thomas R. Hawn
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2025-10-01
シリーズ:	BMC Genomics
主題:	Tuberculosis Alveolar macrophages Resisters Transcriptome
オンライン･アクセス:	https://doi.org/10.1186/s12864-025-12165-w
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