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Bidirectional dysregulation of synaptic glutamate signaling after transient metabolic failure

Ischemia leads to a severe dysregulation of glutamate homeostasis and excitotoxic cell damage in the brain. Shorter episodes of energy depletion, for instance during peri-infarct depolarizations, can also acutely perturb glutamate signaling. It is less clear if such episodes of metabolic failure als...

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Principais autores: Stefan Passlick, Ghanim Ullah, Christian Henneberger
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2024-09-01
Serier:eLife
Fag:
ischemia
synaptic transmission
glutamate release
glutamate uptake
metabolic failure
stroke
Online adgang:https://elifesciences.org/articles/98834
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