Improving effects of melatonin on memory and synaptic potentiation in a mouse model of Alzheimer’s-like disease: the involvement of glutamate homeostasis and mGluRs receptors

Abstract Background Alzheimer's disease (AD) is characterized by progressive cognitive decline and synaptic dysfunction, largely driven by amyloid plaques and neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. These pathological hallmarks disrupt glutamate signaling, which is essent...

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Hlavní autoři:	Narjes Khatoun Shabani Sadr, Fatemeh Bakhtiarzadeh, Koorosh Shahpasand, Javad Mirnajafi-Zadeh, Mehrdad Behmanesh
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-03-01
Edice:	Behavioral and Brain Functions
Témata:	Alzheimer's disease Memory Synaptic plasticity Glutamate signaling Melatonin Metabotropic glutamate receptors
On-line přístup:	https://doi.org/10.1186/s12993-025-00271-4
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