Target-mediated pharmacokinetic/pharmacodynamic model based meta-analysis and dosing regimen optimization of a long-acting release formulation of exenatide in patients with type 2 diabetes mellitus

A hybrid pharmacokinetic/pharmacodynamic (PK/PD) model with extended-release (ER) process and target mediated drug disposition (TMDD) was developed for exenatide ER to account for its complex absorption process and glucagon-like peptide 1 receptor (GLP-1R)-mediated non-linear PK behaviors along with...

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Detalles Bibliográficos
Main Authors: Hanqing Li, Jiayin Xu, Xiaohong Fan
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2015-02-01
Series:Journal of Pharmacological Sciences
Assuntos:
Exenatide extended-release
Model based meta-analysis
Pharmacokinetics
Pharmacodynamics
Dosing regimens
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S1347861314000255
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