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Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate mid-blastula transition events at a low nuclear-cytoplasmic ratio.

Externally deposited eggs begin development with an immense cytoplasm and a single overwhelmed nucleus. Rapid mitotic cycles restore normality as the ratio of nuclei to cytoplasm (N/C) increases. A threshold N/C has been widely proposed to activate zygotic genome transcription and onset of morphogen...

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Príomhchruthaitheoirí: Isaac J T Strong, Xiaoyun Lei, Fang Chen, Kai Yuan, Patrick H O'Farrell
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Public Library of Science (PLoS) 2020-10-01
Sraith:PLoS Biology
Rochtain ar líne:https://doi.org/10.1371/journal.pbio.3000891
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