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Claudin Loss-of-Function Disrupts Tight Junctions and Impairs Amelogenesis

Claudins are a family of proteins that forms paracellular barriers and pores determining tight junctions (TJ) permeability. Claudin-16 and -19 are pore forming TJ proteins allowing calcium and magnesium reabsorption in the thick ascending limb of Henle's loop (TAL). Loss-of-function mutations in the...

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Principais autores: Claire Bardet, Sandy Ribes, Yong Wu, Mamadou Tidiane Diallo, Benjamin Salmon, Tilman Breiderhoff, Pascal Houillier, Dominik Müller, Catherine Chaussain
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017-05-01
Serier:Frontiers in Physiology
Fag:
Amelogenesis Imperfecta
enamel
barrier-forming tight junction protein
pore-forming tight junction protein
claudins
Online adgang:http://journal.frontiersin.org/article/10.3389/fphys.2017.00326/full
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