PARP1-MGMT complex underpins pathway crosstalk in O6-methylguanine repair

Abstract DNA lesions induced by alkylating agents are repaired by two canonical mechanisms, base excision repair dependent on poly(ADP) ribose polymerase 1 (PARP1) and the other mediated by O6-methylguanine (O6meG)-DNA methyltransferase (MGMT) in a single-step catalysis of alkyl-group removal. O6meG...

全面介紹

書目詳細資料

Principais autores:	Jodie D. Cropper, Dauren S. Alimbetov, Kevin T. G. Brown, Rostislav I. Likhotvorik, Andrew J. Robles, James T. Guerra, Boxue He, Yidong Chen, Youngho Kwon, Raushan T. Kurmasheva
格式:	Artigo
語言:	Inglês
出版:	BMC 2022-10-01
叢編:	Journal of Hematology & Oncology
主題:	DNA damage and repair Protein interaction PARP1 MGMT O6-Methylguanine Cancer therapy
在線閱讀:	https://doi.org/10.1186/s13045-022-01367-4
標簽:	添加標簽 沒有標簽, 成為第一個標記此記錄!