PARP1-MGMT complex underpins pathway crosstalk in O6-methylguanine repair
Abstract DNA lesions induced by alkylating agents are repaired by two canonical mechanisms, base excision repair dependent on poly(ADP) ribose polymerase 1 (PARP1) and the other mediated by O6-methylguanine (O6meG)-DNA methyltransferase (MGMT) in a single-step catalysis of alkyl-group removal. O6meG...
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BMC
2022-10-01
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| Colección: | Journal of Hematology & Oncology |
| Materias: | |
| Acceso en línea: | https://doi.org/10.1186/s13045-022-01367-4 |
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