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Determining methylation status of methylguanine DNA methyl transferase (MGMT) from formalin-fixed, paraffin embedded tumor tissue

O-6-methylguanine-DNA methyltransferase (MGMT) has been associated with resistance to alkylating agent cancer therapy in Glioblastoma (GBM), the most common and aggressive primary brain tumor in adults. Lower expression or silencing of the MGMT protein by promoter methylation has been reported to im...

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Principais autores: Francine B. de Abreu, Torrey L. Gallagher, Emmeline Z. Liu, Gregory J. Tsongalis
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2014-01-01
Serier:MethodsX
Fag:
MGMT
O-6-Methylguanine-DNA methyltransferase
Glioblastoma
Methylation
PCR
Online adgang:http://www.sciencedirect.com/science/article/pii/S2215016114000053
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