Structural Basis of Antibody Conformation and Stability Modulation by Framework Somatic Hypermutation

Accumulation of somatic hypermutation (SHM) is the primary mechanism to enhance the binding affinity of antibodies to antigens in vivo. However, the structural basis of the effects of many SHMs remains elusive. Here, we integrated atomistic molecular dynamics (MD) simulation and data mining to build...

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Manylion Llyfryddiaeth

Prif Awduron:	Zizhang Sheng, Jude S. Bimela, Phinikoula S. Katsamba, Saurabh D. Patel, Yicheng Guo, Haiqing Zhao, Youzhong Guo, Peter D. Kwong, Lawrence Shapiro
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2022-01-01
Cyfres:	Frontiers in Immunology
Pynciau:	antibody broadly HIV-1 neutralizing antibody conformation modulation epistasis INDEL molecular dynamics simulation
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.811632/full
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