Structural Basis of Antibody Conformation and Stability Modulation by Framework Somatic Hypermutation

Accumulation of somatic hypermutation (SHM) is the primary mechanism to enhance the binding affinity of antibodies to antigens in vivo. However, the structural basis of the effects of many SHMs remains elusive. Here, we integrated atomistic molecular dynamics (MD) simulation and data mining to build...

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מידע ביבליוגרפי

Principais autores:	Zizhang Sheng, Jude S. Bimela, Phinikoula S. Katsamba, Saurabh D. Patel, Yicheng Guo, Haiqing Zhao, Youzhong Guo, Peter D. Kwong, Lawrence Shapiro
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2022-01-01
סדרה:	Frontiers in Immunology
נושאים:	antibody broadly HIV-1 neutralizing antibody conformation modulation epistasis INDEL molecular dynamics simulation
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.811632/full
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