Structural Basis of Antibody Conformation and Stability Modulation by Framework Somatic Hypermutation

Accumulation of somatic hypermutation (SHM) is the primary mechanism to enhance the binding affinity of antibodies to antigens in vivo. However, the structural basis of the effects of many SHMs remains elusive. Here, we integrated atomistic molecular dynamics (MD) simulation and data mining to build...

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Autors principals:	Zizhang Sheng, Jude S. Bimela, Phinikoula S. Katsamba, Saurabh D. Patel, Yicheng Guo, Haiqing Zhao, Youzhong Guo, Peter D. Kwong, Lawrence Shapiro
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2022-01-01
Col·lecció:	Frontiers in Immunology
Matèries:	antibody broadly HIV-1 neutralizing antibody conformation modulation epistasis INDEL molecular dynamics simulation
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.811632/full
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