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PTEN-mTORC2 signaling module controls antibody isotype selection and antiviral humoral immunity

IntroductionThe phosphoinositide 3-kinase (PI3K) pathway is a central regulator of activated B cells, yet how PI3K signal strength is interpreted within complex signaling networks to achieve appropriate antibody isotype selection and protective humoral immunity remains incompletely understood. Build...

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Principais autores: Bikash Thapa, Yejin Lee, Seongwon Pak, Dongkyu Kim, Hyung-Joo Kwon, Keunwook Lee
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-02-01
coleção:Frontiers in Immunology
Assuntos:
antibody isotype selection
influenza A virus
mTORC2
Notch
phosphoinositide 3-kinase pathway
PTEN
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1771230/full
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